The Reds are out for revenge against their Turkish counterparts, who beat them 1-0 in this fixture earlier in the campaign.
Now, however, the Reds are back at near full strength, barring their four long-term injury absentees.
Alexander Isak, Conor Bradley, Wataru Endo and Giovanni Leoni all miss out, but Florian Wirtz is back in action after missing the last three matches with a back problem.
Liverpool are still chasing a top-four finish in the Premier League, but stumbled last time out as they were beaten dramatically by bottom side Wolves last week.
They got their revenge at Molineux just days later in the FA Cup, but they were helped by Newcastle beating Manchester United.
Chelsea, meanwhile, reeled Aston Villa into the scrap with a 4-1 win at Villa Park.
How to watch Galatasaray vs Liverpool
TV channel: In the UK, the game will be televised live on TNT Sports 1, with coverage starting at 5pm GMT ahead of a 5.45pm kick-off.
Live stream: TNT Sports subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog!
